The Histology Guide

Basic common structure

diagram of layers

The basic plan of all the blood vessels (except the capillaries) that make up the cardiovascular system consists of these three layers.

The walls of the cardiovascular system have a single layer of muscle while those of the gastrointestinal tract for example have two, or in some regions three, layers of muscle.

questionHow could you explain this difference?

Tunica adventitia

diagram of tunica adventitia

This is the outermost coat. It consists of a simple squamous epithelium, basement membrane, connective tissue, blood vessels, and sometimes smooth muscle cells.

This layer needs its own blood supply because it is quite thick. The blood vessels that supply the tunica adventitia are called vasa vasorum (vessels of the vessels).

Tunica media

diagram of tunica media

This consists of concentric layers of smooth muscle fibres and elastin. Some small blood vessels lack muscle fibres and elastin.

Tunica intima

diagram of tunica intima

This is the innermost coat. In blood vessels the simple squamous lining cells (epithelium) is called the endothelium. The tunica intima consists of the endothelium and underlying basement membrane. A small amount of subendothelial connective tissue and and internal elastic layer (lamina), is sometimes present in some blood vessels.