The Histology Guide

Oesophagus

Function of the Oesophagus

diagram of mouth and oesophagus

The oesophagus is a muscular tube through which food is carried from the pharynx to the stomach. Like the rest of the lining of the GI tract, it has to be protective, as it is open to the outside. The oesophagus also has to accomodate a wide variety of food and drink (hot, cold, spicy etc).

Swallowing if voluntary, and involves the skeletal muscles of the oropharynx. After this a strong peristaltic reflex coveys the food or drink to the stomach. This usually only takes a few seconds.

At the junction with the stomach (oesophago-gastic junction), there is a sphincter, which usually prevents reflux or regurgitation.

Layers of the Oesophagus

This photograph shows a a transverse section of the oesophagus at low power, so you can see almost all of the whole oesophagus, including its four layers: - mucosa, submucosa, muscularis externa, and adventitia.

Identify these four layers, and the lumen of the oesophagus.

The oesophagus has a folded appearance. When swallowing food, it is able to distend, and accomodate the food being swallowed on its way to the stomach.

Oesophageal Epithelium

This photograph shows the lining epithelium of the oesophagus at high power. What type of epithelium is it?

Just like the epithelium lining the skin, the basal layer is a layer of dividing cells, which proliferate and constantly move upwards, continuously replacing the lining of the epithelium.

Make sure you can identify pyknotic cells at the lumen, and the layer of dividing cells in the photograph on the left hand side.

Oesophogeal Mucosa

Remember, the mucosa consists of the epithelium, underlying lamina propria and muscularis mucosa.

The lamina propria contains lymphatic capillaries, blood capilaries, and loose connective tissue. The darkly staining cells in the lamina propria are lymphoid aggregations (see the topic on lymphoid tissue to know more).

The muscularis mucosa is a thin, double layer of smooth muscle, more substantial in the lower part of the oesophagus.

Make sure you can identify the epithelium, lamina propria and muscularis mucosa in the photograph on the left hand side.

Other layers of the Oesophagus

photo of upper oesophagus

The submucosa is highly vascular, and contains loose connective tissue. It contains oesophageal glands, that secrete mucus to help ease the passage of swallowed food.

The muscularis externa layer in the top third of the oesophagus contains skeletal muscle, in the middle, it is a mixture of smooth and skeletal muscle, and in the bottom third it is entirely smooth. This photograph shows an example of the muscle layers from teh upper oesophagus.

Now see if you can tell what's wrong with this section of oesophagus.